Alma L. Burlingame

About

Alma L. Burlingame is a pioneering figure in the field of mass spectrometry-based proteomics, whose research has profoundly shaped how scientists identify and characterize proteins in complex biological systems. Working at the intersection of analytical chemistry and molecular biology, Burlingame has made landmark contributions to the development and application of advanced mass spectrometric techniques for protein analysis. Her highly cited 2003 study, which has garnered 295 citations, demonstrated an innovative protocol combining cleavable 13C isotope-coded affinity tag (cICAT) reagents with multidimensional chromatography, enabling researchers to identify and compare protein content from extraordinarily small and complex samples — a breakthrough with far-reaching implications for biomedical research. Her earlier work on the nuclear pore complex of *Saccharomyces cerevisiae* further illustrated her commitment to applying high-throughput MALDI-TOF tandem mass spectrometry to unravel intricate protein-protein interactions. Burlingame's contributions have helped establish mass spectrometry as the gold standard for proteomics research, equipping scientists worldwide with more sensitive, reliable tools for exploring the molecular underpinnings of cellular function and disease.

Research Focus

Key Achievements

Top Papers

1. 1
   Mass Spectrometric Analysis of Protein Mixtures at Low Levels Using Cleavable 13C-Isotope-coded Affinity Tag and Multidimensional Chromatography

   295 citations · 2003
2. 2
   The Identification of Protein-Protein Interactions of the Nuclear Pore Complex of Saccharomyces cerevisiae Using High Throughput Matrix-assisted Laser Desorption Ionization Time-of-Flight Tandem Mass Spectrometry

   38 citations · 2002

Key Collaborators

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