Keng‐Ku Liu

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About

Keng-Ku Liu is a pioneer in nanoplasmonic biodetection, whose work bridges materials science and analytical chemistry to enable highly sensitive, label-free molecular sensing. His primary research areas include surface-enhanced Raman scattering (SERS), plasmonic nanostructure fabrication, and multiplexed chemical detection. Liu’s most significant contribution is the development of “plasmonic calligraphy”—a technique that uses a pen-like device to write plasmonic nanostructures onto arbitrary surfaces, creating SERS-active substrates with unprecedented spatial control. This innovation, detailed in his 2014 paper (45 citations), allows for the multiplexed, charge-selective detection of multiple target analytes from complex mixtures, a critical capability for real-world diagnostics and environmental monitoring. His follow-up work on “bioplasmonic calligraphy” (30 citations) extended this approach to label-free biodetection, demonstrating its utility in identifying biomolecules without fluorescent tags. Together, these papers have laid the foundation for portable, low-cost SERS platforms that can be deployed in field settings. Liu’s work is notable for its elegant simplicity—turning a common writing instrument into a tool for advanced nanofabrication—and its direct impact on the practical application of plasmonics in chemical and biological sensing.