Evan D. Kharasch

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About

Evan D. Kharasch is a pioneering anesthesiologist and clinical pharmacologist whose research has fundamentally advanced the understanding of drug metabolism, anesthesia safety, and perioperative medicine. His work centers on the molecular mechanisms of cytochrome P450 enzymes, particularly how genetic variability and drug interactions influence the metabolism of volatile anesthetics and opioids. Kharasch’s landmark studies on the biotransformation of sevoflurane and desflurane revealed critical pathways for nephrotoxicity, directly shaping clinical guidelines for anesthetic selection. He has also made seminal contributions to the pharmacology of methadone and fentanyl, elucidating their metabolism and drug-drug interactions that impact pain management and addiction treatment. With over 500 publications and more than 25,000 citations, his work is among the most influential in anesthesiology. Notably, his research on bioplasmonic calligraphy for multiplexed label-free biodetection (2014, 30 citations) exemplifies his innovative approach to integrating nanotechnology with clinical diagnostics. A recipient of the ASA Excellence in Research Award, Kharasch’s legacy lies in translating mechanistic pharmacology into safer, more personalized anesthetic care.