Hyeong-Joo Choi

Pohang University of Science and Technology

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About

Dr. Hyeong-Joo Choi is a leading figure in macromolecular crystallography and synchrotron beamline instrumentation, whose work has significantly advanced structural biology infrastructure in Korea. As a key contributor to the Pohang Light Source II (PLS-II), Dr. Choi spearheaded the highly automated upgrade of the BL-5C beamline, a dedicated in-vacuum undulator facility for macromolecular crystallography (MX). This major achievement, detailed in their highly cited 2021 paper, delivered a transformative X-ray source delivering a focused beam spot of 200 µm × 40 µm across a 6.5–16.5 keV energy range, with a measured flux of 7 × 10¹¹ photons. By enabling high-throughput, automated data collection, this upgrade has dramatically accelerated structural studies of biological macromolecules, making cutting-edge crystallography accessible to a broader research community. Dr. Choi’s contributions are foundational to the success of PLS-II, directly supporting thousands of experiments that have led to critical insights into protein function, drug design, and disease mechanisms. Their work exemplifies the vital role of beamline scientists in pushing the boundaries of structural biology, with the BL-5C upgrade serving as a benchmark for modern synchrotron facilities worldwide.