Hiroshi Iseki

About

Hiroshi Iseki is a pioneering neurosurgeon and biomedical engineer whose career has been defined by the integration of robotics, imaging technology, and precision surgery to advance the field of neurosurgery. Working at the intersection of engineering and medicine, Iseki has made landmark contributions to MRI-compatible surgical robotics, most notably his 1995 development of a needle insertion manipulator for stereotactic neurosurgery — a groundbreaking achievement that has accumulated over 300 citations and helped establish a new paradigm for intraoperative imaging-guided intervention. His subsequent work on endoscopic manipulators compatible with open MRI systems and the EXPERT intelligent armrest further demonstrated his commitment to enhancing surgical precision and reducing surgeon fatigue. Iseki has also been a champion of robotic microradiosurgery, pioneering the application of Gamma Knife technology with automatic positioning systems for challenging tumors including pituitary adenomas, craniopharyngiomas, and skull base meningiomas. His innovative fusion of 5-aminolevulinic acid fluorescence guidance with robotic laser ablation represents a truly integrated diagnostic-therapeutic approach. Across more than two decades, Iseki's body of work has reshaped how neurosurgeons conceptualize precision, safety, and technological assistance in the operating room.

Research Focus

Key Achievements

Top Papers

1. 1
   Development of an MRI-compatible needle insertion manipulator for stereotactic neurosurgery

   304 citations · 1995
2. 2
   An integrated diagnosis and therapeutic system using intra-operative 5-aminolevulinic-acid-induced fluorescence guided robotic laser ablation for precision neurosurgery

   69 citations · 2010
3. 3
   Gamma Knife robotic microradiosurgery of pituitary adenomas invading the cavernous sinus: treatment concept and results in 89 cases

   57 citations · 2010
4. 4
   The Concept and Feasibility of EXPERT

   51 citations · 2012
5. 5
   Endoscope Manipulator for Trans-nasal Neurosurgery, Optimized for and Compatible to Vertical Field Open MRI

   44 citations · 2002
6. 6
   Stereotactic Radiosurgery of Residual or Recurrent Craniopharyngioma: New Treatment Concept Using Leksell Gamma Knife Model C with Automatic Positioning System

   41 citations · 2009
7. 7
   Development of an MRI-Compatible Needle Insertion Manipulator for Stereotactic Neurosurgery

   37 citations · 1995
8. 8
   A newly developed stereotactic robot with detachable drive for neurosurgery

   24 citations · 1998
9. 9
   Gamma Knife Robotic Microradiosurgery for Benign Skull Base Meningiomas: Tumor Shrinkage May Depend on the Amount of Radiation Energy Delivered per Lesion Volume (Unit Energy)

   21 citations · 2010
10. 10
    Combination of Intraoperative 5-Aminolevulinic Acid-Induced Fluorescence and 3-D MR Imaging for Guidance of Robotic Laser Ablation for Precision Neurosurgery

    19 citations · 2008

Key Collaborators

Contact & Links