Gregory H. Underhill
Papers
2
Total Citations
34
H-Index
2
About
Gregory H. Underhill is a leading investigator in hepatic tissue engineering and regenerative medicine, with a core focus on how the extracellular matrix (ECM) and biophysical cues govern liver cell behavior. His work has been instrumental in unraveling the cooperative roles of ECM protein composition and tissue stiffness in regulating primary human hepatocyte (PHH) phenotype—a critical challenge for drug screening and cell-based therapies. Using innovative protein microarrays and high-content single-cell imaging, Underhill demonstrated how combinatorial ECM microenvironments can modulate the maturation and function of human iPSC-derived hepatocytes, a breakthrough that has garnered over 21 citations in a short time. His research not only provides fundamental insights into liver biology but also establishes scalable platforms for hepatocyte engineering. Underhill’s contributions are shaping the future of personalized liver models and regenerative strategies, making him a key figure in the intersection of biomaterials, stem cell biology, and hepatic physiology.
Research Focus
Key Achievements
Top Papers
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