Chase P. Monckton
Papers
2
Total Citations
34
H-Index
2
About
Chase P. Monckton is a biomedical researcher whose work centers on liver tissue engineering and the role of the extracellular matrix (ECM) in regulating hepatocyte function. His research primarily investigates how ECM composition and mechanical stiffness cooperatively control the phenotype of both primary human hepatocytes (PHHs) and iPSC-derived hepatocytes—critical knowledge for developing better in vitro liver models and cell-based therapies. In his most cited work, "Modulation of human iPSC-derived hepatocyte phenotype via extracellular matrix microarrays" (2022, 21 citations), Monckton pioneered the use of protein microarrays to screen how different ECM proteins influence stem cell-derived liver cell maturation. His earlier study, "Elucidating Extracellular Matrix and Stiffness Control of Primary Human Hepatocyte Phenotype via Cell Microarrays" (2021, 13 citations), systematically revealed how the liver's native ECM protein composition and substrate stiffness together regulate PHH attachment and function at single-cell resolution. By employing high-content imaging and combinatorial ECM screening, Monckton has provided foundational insights into the microenvironmental cues that maintain hepatocyte identity. His work bridges materials science and stem cell biology, offering a platform to optimize culture conditions for drug toxicity testing and regenerative medicine applications.
Research Focus
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Top Papers
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