Fengsong Liu

National Center for Nanoscience and Technology

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About

Fengsong Liu is a leading researcher at the intersection of DNA nanotechnology and plasmonics, with a primary focus on engineering intelligent, logic-gated nanodevices. His most cited work, "Logic-Gated Plasmonic Nanodevices Based on DNA-Templated Assembly" (2020, 23 citations), published in *CCS Chemistry*, represents a significant breakthrough in the field. In this study, Liu and his colleagues pioneered the use of DNA origami as a programmable scaffold to precisely organize gold nanoparticles into plasmonic nanostructures that respond to specific molecular inputs. By integrating Boolean logic gates (AND, OR) into the DNA framework, they created nanodevices capable of performing complex computational operations at the nanoscale, with their optical output—a shift in plasmonic resonance—serving as a readout. This work bridges the gap between molecular computing and nanophotonics, offering a powerful platform for smart biosensing and targeted drug delivery. Liu’s contributions are foundational for the development of autonomous, stimuli-responsive nanomaterials. His research, conducted at the CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, continues to push the boundaries of how DNA can be used to build dynamic, functional systems for biomedical and technological applications.