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About

David Hume is a leading figure in functional genomics, best known for his pivotal role in the FANTOM (Functional Annotation of the Mammalian Genome) consortium. His most cited work, the landmark 2017 paper "FANTOM5 CAGE profiles of human and mouse samples" (361 citations), revolutionized our understanding of gene regulation by mapping transcription initiation events across thousands of human and mouse samples at single base-pair resolution. Using Cap Analysis of Gene Expression (CAGE) coupled with single-molecule sequencing, Hume and his team created an unprecedented atlas of promoters and enhancers, revealing the complex, dynamic nature of transcriptional control. This foundational resource has empowered researchers worldwide to explore cell-type-specific gene expression and disease mechanisms. Beyond this, Hume’s contributions extend to immunology and transcriptomics, where his work has shaped how we study regulatory networks. With a career spanning decades and a citation count exceeding 30,000, his impact is immense—his data and insights continue to drive discoveries in molecular biology, making him an indispensable figure for any student or researcher delving into the intricacies of gene regulation.