D.T. Yegian
Papers
2
Total Citations
122
H-Index
2
About
D.T. Yegian is a researcher whose work sits at the intersection of biological engineering and automation, pioneering high-throughput methods to accelerate fundamental biological discovery. Their major contributions lie in developing robotic systems to replace labor-intensive manual processes in both structural biology and genetics. Yegian’s most impactful work, “Automated Sample Mounting and Alignment System for Biological Crystallography at a Synchrotron Source” (2004, 104 citations), revolutionized how protein crystals are handled at synchrotrons, enabling faster, more reliable data collection for structural biologists worldwide. This system automated the delicate task of mounting and centering crystals, dramatically increasing throughput and reducing human error. In a complementary vein, Yegian tackled the bottleneck of fruit fly genetics with “Automating fruit fly Drosophila embryo injection for high throughput transgenic studies” (2008, 18 citations). This work developed an automated instrument for injecting thousands of Drosophila embryos with transgenes, a critical tool for deciphering the 14,000 identified Drosophila genes. By engineering precision automation for both crystallography and transgenesis, Yegian’s work has empowered researchers to scale experiments that were previously painstakingly manual, leaving a lasting impact on how biological research is conducted.
Research Focus
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Top Papers
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