Papers
6
Total Citations
106
H-Index
6
About
Corina Flangea is an analytical biochemist whose research sits at the intersection of mass spectrometry, glycobiology, and neurochemistry. She has made significant contributions to the development and application of chip-based nanoelectrospray ionization mass spectrometry (chip-nanoESI-MS), pioneering its use as a powerful tool for characterizing complex biomolecules in neurological and oncological contexts. Her most influential work, garnering 48 citations, introduced a fully automated chip-nanoESI-MS approach to assess ganglioside expression and structure in brain metastases of lung adenocarcinoma, providing critical insight into the molecular mechanisms driving tumor invasiveness. Complementing this, her studies on brain gangliosides and glycosaminoglycans — including the identification of an unusually sulfated chondroitin/dermatan tetrasaccharide motif in mouse brain — have advanced understanding of how these complex carbohydrates function in neural tissue. Flangea has also demonstrated the translational potential of her methodology by exploring chip-based nanoESI-MS as a rapid diagnostic tool for Fabry disease, a lysosomal storage disorder. Her work in top-down proteomics further showcases her versatility in developing high-throughput analytical platforms. Collectively, her research has meaningfully expanded the toolkit available to glycoscientists and clinical researchers alike.
Research Focus
Key Achievements
Top Papers
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- 2Chip-based nanoelectrospray mass spectrometry of brain gangliosides21 citations · 2011
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