Papers
4
Total Citations
96
H-Index
4
About
Alina Serb is a analytical biochemist whose research has made significant contributions to the structural and molecular characterization of gangliosides — complex sialic acid-containing glycosphingolipids that play critical roles in brain function and tumor biology. Her work has pioneered the application of chip-based nanoelectrospray mass spectrometry as an advanced analytical platform for profiling and sequencing gangliosides from human brain tissues and pathological specimens. Serb's most influential contribution, garnering 48 citations, demonstrated the power of fully automated chip-nanoelectrospray mass spectrometry in uncovering molecular expression changes in gangliosides associated with brain metastasis of lung adenocarcinoma — a finding with important implications for understanding the invasive behavior of metastatic brain tumor cells. Her complementary studies on ganglioside profiles in healthy human brain regions, including the caudate nucleus, have helped establish baseline molecular signatures essential for distinguishing normal from neoplastic tissue. With a cumulative citation record reflecting growing recognition within the glycoscience and neuro-oncology communities, Serb's methodological innovations have positioned chip-based mass spectrometry as a powerful tool for glycolipid research, offering researchers a more precise and efficient means of linking ganglioside structural diversity to specialized brain functions and disease states.
Research Focus
Key Achievements
Top Papers
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- 2Chip-based nanoelectrospray mass spectrometry of brain gangliosides21 citations · 2011
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