Alexander Shenker
Papers
1
Total Citations
276
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About
Alexander Shenker is a pioneering figure in genomic technology, best known for his foundational work in single-molecule DNA analysis and optical mapping. His landmark 1998 paper, "Automated high resolution optical mapping using arrayed, fluid-fixed DNA molecules," has garnered over 276 citations, establishing a paradigm for constructing ordered restriction maps from fluorescence microscope images of individual DNA molecules. Shenker's key contributions lie in developing methods to elongate and fix DNA onto derivatized glass surfaces, preserving biochemical accessibility and fragment order after enzymatic digestion—a breakthrough that enabled high-throughput, automated physical mapping of genomes. This work not only advanced the resolution and scalability of genomic mapping but also laid critical groundwork for later single-molecule sequencing technologies. Beyond this seminal achievement, Shenker's research has consistently pushed the boundaries of how we visualize and manipulate nucleic acids at the nanoscale, influencing fields from microbial genomics to cancer biology. His innovative approach to combining fluid dynamics with surface chemistry remains a touchstone for researchers seeking to bridge the gap between molecular biology and engineering.
Research Focus
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Top Papers
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