DNA sequencer
Related papers: 20
About
A DNA sequencer is an instrument that determines the precise order of nucleotide bases (adenine, thymine, cytosine, and guanine) within a DNA molecule. Modern sequencers employ techniques such as dideoxy chain termination, fluorescent labeling, capillary electrophoresis, and next-generation sequencing approaches to read genetic sequences rapidly and accurately. In robotics and AI contexts, DNA sequencers are frequently integrated into automated laboratory workflows, where robotic workstations handle sample preparation, template purification, and reaction setup, enabling high-throughput processing of thousands of samples with minimal human intervention. Automation reduces pipetting errors, improves reproducibility, and dramatically accelerates throughput — capabilities essential to large-scale initiatives like the Human Genome Project. AI and machine learning algorithms further enhance sequencing pipelines by interpreting raw fluorescence signals, detecting mutations, correcting base-calling errors, and managing complex data workflows. DNA sequencers matter because they underpin advances in personalized medicine, infectious disease surveillance, genetic diagnostics, and synthetic biology, making automated, high-fidelity sequencing infrastructure a cornerstone of modern biotechnology and biomedical research.
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Hybridisation based DNA screening on peptide nucleic acid (PNA) oligomer arrays
Jan Weiler
Citations: 219 • 1997
Evolution of Hybridization Probes to DNA Machines and Robots
Dmitry M. Kolpashchikov
Citations: 66 • 2019
Sequence length and error analysis of Sequenase and automated Taq cycle sequencing methods.
Ben F. Koop, Linda Rowan, W.Q. Chen, Purnima Deshpande, H Lee, L Hood
Citations: 56 • 1993
Development of an automated procedure for fluorescent DNA sequencing
Richard K. Wilson, Chia Chen, Nebojša Avdalović, James M. Burns, Leroy Hood
Citations: 46 • 1990
Sequencing by hybridization: Towards an automated sequencing of one million M13 clones arrayed on membranes
Radoje Drmanac, Snezana Drmanac, Ivan Labat, Radomir Crkvenjakov, Aleksandra Vicentic, Anne Gemmell
Citations: 46 • 1992
Automated Pneumococcal MLST Using Liquid-Handling Robotics and a Capillary DNA Sequencer
Johanna M. Jefferies, Stuart C. Clarke, Mathew Diggle, Andrew Smith, Christopher G. Dowson, Timothy J. Mitchell
Citations: 38 • 2003
Semi-Automated Library Preparation for High-Throughput DNA Sequencing Platforms
Eveline Farias‐Hesson, Jonathan Erikson, Alexander Atkins, Peidong Shen, Ronald W. Davis, Curt Scharfe, Nader Pourmand
Citations: 36 • 2010
Automated methods for single-stranded DNA isolation and dideoxynucleotide DNA sequencing reactions on a robotic workstation.
Elaine R. Mardis, B.A. Roe
Citations: 31 • 1989
Automated Workflow for Preparation of cDNA for Cap Analysis of Gene Expression on a Single Molecule Sequencer
Masayoshi Itoh, Miki Kojima, Sayaka Nagao-Sato, Eri Saijo, Timo Lassmann, Mutsumi Kanamori-Katayama, Ai Kaiho, Marina Lizio, Hideya Kawaji, Piero Carninci, Alistair R. R. Forrest, Yoshihide Hayashizaki
Citations: 27 • 2012
DNA sequencing
H Griffin, Annette M. Griffin
Citations: 27 • 1993
[35] Automated sequencing of mitochondrial DNA
Masashi Tanaka, Mika Hayakawa, Takayuki Ozawa
Citations: 26 • 1996
Semiautomated DNA Mutation Analysis Using a Robotic Workstation and Molecular Beacons
Maarten L. Smit, B. Giesendorf, Jacqueline A. M. Vet, Frans J.M. Trijbels, Henk J. Blom
Citations: 25 • 2001
Whose Genome Is It, Anyway?
Eliot Marshall
Citations: 19 • 1996
Automated PCR/Sequence Template Purification
Stuart C. Clarke, Mathew Diggle
Citations: 16 • 2002
An improved high throughput heteroduplex mutation detection system for screeningBRCA2 mutations?fluorescent mutation detection (F-MD)
S M Edwards, Zsofia Kote‐Jarai, Rifat Hamoudi, Rosalind A. Eeles
Citations: 16 • 2001
Fully-automated, nonradioactive solid-phase sequencing of genomic DNA obtained from PCR.
A. Rolfs, Irene T. Weber
Citations: 15 • 1994
The use of exonuclease III deletions in automated DNA sequencing
W RICHARDMCCOMBIE, Ewen F. Kirkness, J Fleming, Anthony R. Kerlavage, D. M. Iovannisci, Antonia Martín-Gallardo
Citations: 11 • 1991
Cascading DNA Generation Reaction for Controlling DNA Nanomachines at a Physiological Temperature
Ken Komiya, Masayuki Yamamura
Citations: 10 • 2015
Implementation of automation in a small-scale DNA sequencing core facility.
Jennifer Ware, L. Moran, Chu Lin, Barton E. Slatko
Citations: 6 • 2000
Sequencing Support System: A robotic system for processing DNA samples
S. Brignac
Citations: 3 • 1997