William P. J. Leenders
Papers
1
Total Citations
99
H-Index
1
About
Dr. William P. J. Leenders is a leading figure in translational cancer research, with a primary focus on tumor angiogenesis, metastasis, and the development of innovative preclinical models. His major contributions center on understanding the complex biology of the tumor vasculature, particularly how it differs from normal blood vessels, and exploiting these differences for targeted therapies and imaging. He has pioneered the use of zebrafish larvae as high-throughput, in vivo models for studying cancer progression and drug screening, as evidenced by his highly cited work on robotic injection of zebrafish embryos (99 citations), which has enabled rapid, automated analysis of disease mechanisms. Dr. Leenders’ research has significantly advanced our knowledge of how tumors co-opt the lymphatic system for metastasis and how anti-angiogenic therapies can paradoxically promote tumor spread. His work bridges fundamental biology and clinical application, providing critical insights that inform the development of more effective cancer treatments. With a career spanning decades, his highly cited publications have shaped the field of vascular biology in cancer, making him an influential voice in the quest to understand and combat metastatic disease.
Research Focus
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Top Papers
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