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About

Jan de Sonneville is a pioneering researcher specializing in high-throughput screening technologies, zebrafish biomedical models, and automated laboratory systems for disease research. Working at the intersection of robotics and biology, de Sonneville has made significant contributions to accelerating drug discovery and disease modeling through innovative automation approaches. His most impactful work, "A High-Throughput Screen for Tuberculosis Progression" (2011, 126 citations), addressed a critical bottleneck in tuberculosis research by developing a whole-organism screening system at a time when multi-drug resistant strains posed an escalating global threat. Complementing this, his widely cited development of robotic injection systems for zebrafish embryos (2013, 99 citations) revolutionized how researchers use these transparent, genetically tractable organisms to model human diseases efficiently and at scale. De Sonneville has continued advancing zebrafish methodology, applying automated microinjection to cancer xenograft models and CRISPR-based RNA silencing systems, demonstrating consistent innovation across oncology and gene-editing applications. His interdisciplinary reach further extends to ecotoxicology, where automated sorting technologies improve bioconcentration studies in crustaceans. Collectively, his body of work underscores a career dedicated to making complex biological research faster, more reproducible, and more translationally relevant.