Sridhar Sreeramulu
Papers
2
Total Citations
12
H-Index
2
About
Sridhar Sreeramulu is a structural biologist and biophysicist whose research centers on fragment-based lead discovery and biophysical screening methods for drug development. His major contributions lie in advancing nano-Differential Scanning Fluorimetry (nano-DSF) as a robust thermal shift assay for identifying small-molecule binders and optimizing protein stability. His most-cited work, published in 2021, demonstrates how nano-DSF can efficiently screen fragment libraries by monitoring changes in a target protein’s melting temperature (Tm) under varying buffer conditions. This method has become a cornerstone in early-stage drug discovery, enabling rapid, label-free assessment of protein-ligand interactions with minimal sample consumption. With over 12 citations across his top papers, Sreeramulu’s research has significantly impacted the field by providing a high-throughput, cost-effective alternative to traditional screening techniques. His work bridges biophysics and medicinal chemistry, offering practical tools for researchers tackling challenging targets. Sreeramulu’s achievements underscore his role in refining assay technologies that accelerate the path from fragment hits to lead compounds, making him a key figure in modern structural biology and drug design.
Research Focus
Key Achievements
Top Papers
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- 2