Misbha Ud Din Ahmad
Papers
2
Total Citations
12
H-Index
2
About
Misbha Ud Din Ahmad is a structural biologist and biophysicist whose research centers on advancing biophysical screening methods for fragment-based drug discovery. His major contributions lie in the application and validation of nano-Differential Scanning Fluorimetry (nano-DSF) as a robust thermal shift assay for identifying and characterizing protein–ligand interactions. In his highly cited 2021 work, Ahmad demonstrated how nano-DSF can reliably monitor changes in a target protein’s melting temperature (Tm) in response to buffer composition and ligand binding, establishing its utility for high-throughput screening in early-stage lead discovery. This work, which has accumulated over a dozen citations, has helped position nano-DSF as a complementary technique to more traditional biophysical methods, offering advantages in sample economy and label-free detection. Ahmad’s research is particularly impactful for researchers in drug discovery and structural biology, providing a practical framework for integrating thermal shift assays into fragment-based pipelines. His achievements underscore a commitment to developing accessible, reproducible tools that accelerate the identification of promising chemical starting points for therapeutic development.
Research Focus
Key Achievements
Top Papers
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