Ramona Mannino
Papers
1
Total Citations
124
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1
About
Dr. Ramona Mannino is a leading genetic epidemiologist whose research focuses on the genetic architecture of pregnancy-related liver disorders, particularly intrahepatic cholestasis of pregnancy (ICP). Her landmark 2013 study, "A Comprehensive Analysis of Common Genetic Variation Around Six Candidate Loci for Intrahepatic Cholestasis of Pregnancy," has garnered 124 citations and fundamentally advanced our understanding of ICP's complex genetic etiology. In this work, Dr. Mannino systematically investigated common genetic variants beyond the known heterozygous mutations in canalicular transporters and the ABCB11 p.444A susceptibility allele, demonstrating that ICP susceptibility involves a broader polygenic landscape. Her contributions have been instrumental in bridging the gap between rare Mendelian mutations and common variant associations in hepatobiliary disease during pregnancy. By elucidating the genetic factors that predispose women to this potentially serious condition, Dr. Mannino's research has paved the way for improved risk stratification and clinical management. Her work remains essential reading for researchers in reproductive genetics and hepatology, establishing her as a key figure in understanding the molecular mechanisms underlying pregnancy-specific liver dysfunction.
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