Meera Sothinathan
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124
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About
Dr. Meera Sothinathan is a leading genetic epidemiologist whose research centers on the genetic architecture of pregnancy-related liver disorders, particularly intrahepatic cholestasis of pregnancy (ICP). Her seminal work, "A Comprehensive Analysis of Common Genetic Variation Around Six Candidate Loci for Intrahepatic Cholestasis of Pregnancy" (2013, 124 citations), represents a landmark contribution to the field. In this study, Dr. Sothinathan systematically investigated common genetic variants surrounding key canalicular transporter genes, including ABCB11, where she helped characterize the population susceptibility allele p.444A. Her findings significantly advanced understanding of ICP's complex polygenic etiology, demonstrating that both rare heterozygous mutations and common variants contribute to disease risk. This work has been instrumental in shaping subsequent genetic screening approaches for ICP and has informed clinical risk assessment for affected pregnancies. Dr. Sothinathan's research bridges molecular genetics and clinical obstetrics, providing critical insights into how genetic predisposition interacts with environmental factors during pregnancy. Her contributions have been widely recognized, with her work serving as a foundational reference for researchers investigating hepatobiliary disorders of pregnancy.
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