Argyro Syngelaki
Papers
1
Total Citations
124
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1
About
Dr. Argyro Syngelaki is a leading figure in maternal-fetal medicine, whose research has fundamentally advanced our understanding of the genetic underpinnings of pregnancy complications. Her primary focus lies in the genetics of intrahepatic cholestasis of pregnancy (ICP), a liver disorder that poses significant risks to both mother and fetus. In her highly cited 2013 study (124 citations), Dr. Syngelaki conducted a comprehensive analysis of common genetic variation around six key candidate loci, moving beyond rare mutations to identify population-level susceptibility alleles. This work was pivotal in demonstrating that ICP has a complex, polygenic etiology, with common variants in genes like ABCB11 playing a substantial role. By meticulously dissecting the genetic architecture of the disease, her contributions have provided crucial insights for risk stratification and opened new avenues for understanding the pathophysiology of cholestasis. Dr. Syngelaki’s research is distinguished by its rigorous methodology and its direct clinical relevance, helping to shape how clinicians approach the diagnosis and management of this high-risk condition. Her work remains a cornerstone for subsequent genetic studies in obstetric hepatology.
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