Patrick D. Shaw Stewart
Papers
3
Total Citations
51
H-Index
3
About
Patrick D. Shaw Stewart is a specialist in protein crystallization methodology, with research focused on developing and refining techniques that improve the efficiency and success rates of producing high-quality protein crystals for X-ray diffraction studies. His work sits at a critical intersection of structural biology and biochemical engineering, addressing one of the most persistent bottlenecks in determining protein structures. Among his most significant contributions is the development and promotion of random microseed matrix screening (rMMS), a technique that introduces seed crystals into randomized screening conditions to encourage crystal growth within the metastable zone of a protein's phase diagram. This approach reliably generates additional crystallization leads and improves overall crystal quality, representing a meaningful advance for structural biologists worldwide. His 2013 papers on rMMS have accumulated over 30 citations combined, reflecting strong uptake within the crystallography community. Shaw Stewart has also made practical engineering contributions, including a modification to the Douglas Instruments ORYX crystallization robot that doubled its screening capacity, alongside novel screening and optimization strategies that substantially reduce the number of trials needed to produce diffraction-quality crystals. His applied, problem-solving approach has made protein structure determination more accessible and productive for researchers across structural biology.
Research Focus
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Top Papers
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