Stefan Kolek
Papers
2
Total Citations
31
H-Index
2
About
Stefan Kolek is a structural biologist whose work centers on overcoming one of the most stubborn bottlenecks in macromolecular crystallography: protein crystallization. His primary research area focuses on developing and refining techniques to reliably produce high-quality protein crystals for X-ray diffraction. Kolek’s major contribution is the development of Random Microseed Matrix Screening (rMMS), a powerful method that introduces seed crystals into random crystallization screens. This approach dramatically increases the probability of growing crystals in the metastable zone of a protein’s phase diagram, yielding more and better crystallization leads than traditional methods. His seminal paper on rMMS, published in 2013, has accumulated over 30 citations, underscoring its significance in the field. By providing a simple, robust protocol that can be integrated into existing high-throughput workflows, Kolek has helped researchers salvage difficult targets and improve crystal quality for structure determination. His work is a testament to how methodological innovation can accelerate discovery in structural biology, making him a key figure for students and researchers seeking to master the art and science of protein crystallization.
Research Focus
Key Achievements
Top Papers
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