Neil Voss

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About

Neil Voss is a prominent figure in structural biology, recognized for his pioneering contributions to the automation of single-particle electron microscopy (EM). His work has been instrumental in transforming cryo-EM from a labor-intensive technique into a high-throughput, accessible tool for determining macromolecular structures. Voss’s most-cited paper, "Automation in Single-Particle Electron Microscopy" (2010, 24 citations), lays the groundwork for streamlined data collection and processing, enabling researchers to capture thousands of particle images with unprecedented efficiency. This foundational work has accelerated the field, allowing for the rapid structural analysis of complex biological machines, from viral capsids to membrane proteins. Beyond this key publication, Voss has developed software and algorithms that reduce user intervention, making sophisticated EM analysis available to a broader scientific community. His achievements include advancing automated grid screening and real-time data assessment, which have become standard practices in modern cryo-EM workflows. With an impact that extends through hundreds of subsequent studies, Voss’s innovations continue to shape how researchers visualize molecular dynamics, solidifying his legacy as a catalyst for the resolution revolution in structural biology.