Papers
5
Total Citations
111
H-Index
4
About
Mikako Saito is a pioneer in single-cell manipulation and bioelectrochemistry, whose work has fundamentally transformed the precision and throughput of microinjection technology. Her research focuses on developing robotic systems for high-performance single-cell engineering, enabling researchers to overcome the traditional difficulty of manual microinjection. Saito’s major contribution is the invention of the single-cell manipulation supporting robot (SMSR), which allows for high-throughput, semi-quantitative introduction of femtogram-level DNA and molecules into individual cells. Her most cited work, "High throughput easy microinjection with a single-cell manipulation supporting robot" (2004, 82 citations), established a new standard for reproducibility and efficiency in the field. She further demonstrated the power of this technology by performing femtoinjection of EGFP and Oct3/4 expression vectors into mouse embryonic stem cells, enabling semi-quantitative analysis of transient gene expression and differentiation pathways. Saito’s innovations bridge engineering and biology, offering a robust platform for single-cell injectoassay and bioelectrochemistry. Her work is essential reading for researchers seeking to manipulate stem cells or analyze gene function at the single-cell level with unprecedented control and scalability.
Research Focus
Key Achievements
Top Papers
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- 5Single-Cell Injectoassay for ES Cell Engineering3 citations · 2009