Papers
5
Total Citations
111
H-Index
4
About
Hideaki Matsuoka has pioneered the development of high-throughput microinjection technologies, transforming a traditionally difficult and manual technique into a precise, automated process for single-cell manipulation. His key research areas include single-cell bioelectrochemistry, embryonic stem cell engineering, and gene expression analysis at the individual cell level. Matsuoka’s major contribution is the invention of the single-cell manipulation supporting robot (SMSR), which enables rapid, semi-quantitative femtoinjection of DNA and other molecules into living cells. This breakthrough allows researchers to introduce precise femtogram quantities of genetic material—such as EGFP or Oct3/4 expression vectors—directly into mouse embryonic stem cells, facilitating controlled studies of gene expression and differentiation. His most cited work, "High throughput easy microinjection with a single-cell manipulation supporting robot" (2004, 82 citations), established the foundation for this field. Matsuoka’s innovations have made single-cell injectoassays practical, opening new avenues for stem cell engineering and quantitative biology. His work continues to empower researchers to explore gene function with unprecedented accuracy and throughput.
Research Focus
Key Achievements
Top Papers
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- 5Single-Cell Injectoassay for ES Cell Engineering3 citations · 2009