Michael Rexach

About

Michael Rexach is a distinguished cell biologist whose research has significantly advanced our understanding of nucleocytoplasmic transport and the molecular architecture of the nuclear pore complex (NPC). His work focuses on the intricate protein-protein interactions that govern how molecules move between the nucleus and cytoplasm in eukaryotic cells, with a particular emphasis on yeast (*Saccharomyces cerevisiae*) as a model organism. Among his most notable contributions is the development and application of the innovative "Bead Halo" assay, published in 2007 and accumulating 82 citations, which provided a highly sensitive, equilibrium-based method for detecting novel interactions within the nucleocytoplasmic transport machinery. This tool revealed previously unknown binding relationships between the importin Kap95 and key nucleoporins, reshaping our map of NPC interactions. Earlier, Rexach employed cutting-edge high-throughput MALDI-TOF tandem mass spectrometry to systematically identify protein-protein interactions at the NPC, a methodologically influential study that garnered 38 citations and helped establish proteomics approaches as standard tools in transport biology research. Together, his contributions have provided the field with both conceptual insights and powerful experimental frameworks for dissecting one of the cell's most critical transport systems.

Research Focus

Key Achievements

Top Papers

1. 1
   Discovering Novel Interactions at the Nuclear Pore Complex Using Bead Halo

   82 citations · 2007
2. 2
   The Identification of Protein-Protein Interactions of the Nuclear Pore Complex of Saccharomyces cerevisiae Using High Throughput Matrix-assisted Laser Desorption Ionization Time-of-Flight Tandem Mass Spectrometry

   38 citations · 2002

Key Collaborators

Contact & Links