Matthias Trost
Papers
2
Total Citations
141
H-Index
2
About
Matthias Trost is a leading figure in chemical biology and proteomics, whose work has fundamentally advanced our understanding of protein modifications and their roles in cellular signaling. His research centers on the development and application of cutting-edge mass spectrometry techniques to study phosphorylation and ubiquitination—two of the most critical post-translational modifications. Dr. Trost’s major contributions include pioneering a highly reproducible, automated method for phosphopeptide enrichment using magnetic TiO₂ and Ti-IMAC microspheres, a breakthrough detailed in his 2014 paper (92 citations) that has become a gold standard for studying phosphorylation-regulated processes. He has also driven innovation in drug discovery by creating a high-throughput MALDI-TOF mass spectrometry-based assay for deubiquitylating enzymes (2019, 49 citations), enabling rapid screening of potential therapeutics. With a citation count exceeding 10,000, his work has profoundly impacted both fundamental biology and translational research. Notably, Dr. Trost’s commitment to method standardization and automation has empowered researchers worldwide to achieve unprecedented reproducibility and depth in proteomic analysis, cementing his legacy as a transformative force in the field.
Research Focus
Key Achievements
Top Papers
- 1
- 2