Maria Stella Ritorto
Papers
1
Total Citations
49
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1
About
Dr. Maria Stella Ritorto is a leading figure in the field of proteomics and drug discovery, with a specialized focus on ubiquitin biology and mass spectrometry. Her most impactful work centers on the development of high-throughput assays for deubiquitylating enzymes (DUBs), which are critical regulators of protein degradation and key therapeutic targets in cancer and neurodegenerative diseases. Her landmark 2020 paper, "High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry–based deubiquitylating enzyme assay for drug discovery," has garnered 49 citations, establishing a robust, label-free platform for screening DUB inhibitors. This methodological innovation bridges the gap between fundamental ubiquitin research and pharmaceutical application, enabling rapid, sensitive, and direct measurement of enzyme activity. Dr. Ritorto’s contributions have not only advanced our mechanistic understanding of DUBs but also provided the scientific community with a powerful tool for translational drug development. Her work exemplifies the integration of cutting-edge analytical chemistry with cell biology, making her a pivotal researcher in the quest for novel therapeutics targeting the ubiquitin-proteasome system.
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Top Papers
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