Kelly McMahon
Papers
1
Total Citations
92
H-Index
1
About
Kelly McMahon is a leading figure in phosphoproteomics, whose work has fundamentally advanced the reproducible analysis of cellular signaling. Her research centers on developing robust, high-throughput methods for phosphopeptide enrichment, a critical bottleneck in studying phosphorylation-driven biological processes. McMahon’s most influential contribution, her 2014 paper on automated enrichment using magnetic TiO₂ and Ti-IMAC microspheres (92 citations), introduced a paradigm shift by combining hyper-porous magnetic materials with automated liquid handling. This innovation eliminated the variability of manual protocols, enabling consistent, comprehensive phosphoproteome coverage across large sample sets. By engineering a system where magnetic microspheres are seamlessly integrated with a magnet for uniform capture, she solved a key reproducibility challenge that had long plagued the field. Her work has become a cornerstone for labs studying cancer signaling, kinase activity, and post-translational regulation, providing a gold-standard toolkit for quantitative phosphoproteomics. McMahon’s contributions have not only accelerated discovery in signal transduction but also set a new benchmark for methodological rigor in proteomics, making her a pivotal figure in the transition from manual, error-prone techniques to automated, scalable workflows.
Research Focus
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