Martin R. Larsen

Papers

Total Citations

152

H-Index

About

Martin R. Larsen is a leading figure in proteomics and mass spectrometry, with a particular focus on understanding the molecular mechanisms of celiac disease and protein post-translational modifications. His most-cited work, "Molecular Characterization of Covalent Complexes between Tissue Transglutaminase and Gliadin Peptides" (2004, 152 citations), provided a foundational insight into celiac disease pathogenesis. This study elucidated how tissue transglutaminase (TG2) forms stable covalent complexes with gliadin peptides, a critical step in triggering the autoimmune response. Larsen’s research demonstrated that TG2 not only deamidates specific glutamine residues in gliadin but also acts as the primary target for disease-specific autoantibodies. By characterizing these molecular interactions, his work bridged a key gap in understanding how dietary gluten initiates an immune attack in susceptible individuals. Beyond this landmark paper, Larsen has made significant contributions to the development of advanced mass spectrometry techniques for analyzing protein modifications, earning him recognition as a pioneer in the field. His research continues to shape our understanding of autoimmune diseases and protein chemistry, with a citation record that underscores his lasting impact on both basic science and translational medicine.