Burkhard Fleckenstein

University of Oslo, Oslo University Hospital

Papers

Total Citations

399

H-Index

About

Burkhard Fleckenstein is a leading immunologist whose research has fundamentally advanced our understanding of celiac disease pathogenesis. His work centers on the molecular interplay between dietary gluten, the immune system, and the enzyme tissue transglutaminase (TG2). Fleckenstein’s major contributions include elucidating how TG2 selectively modifies gliadin peptides—either by deamidation or transamidation—to create high-affinity T cell epitopes that drive the autoimmune response in celiac disease. His seminal 2002 paper on this topic has garnered over 230 citations, establishing a cornerstone of modern celiac research. He further characterized the covalent complexes formed between TG2 and gliadin, demonstrating the enzyme’s dual role as both an autoantibody target and a generator of immunogenic peptides. Beyond celiac disease, Fleckenstein has explored innovative approaches to mucosal immunity, including the identification of a phage-displayed peptide that exploits the polymeric Ig receptor for epithelial transcytosis. His work has profound implications for understanding autoimmune mechanisms and developing targeted therapies, making him a highly cited and influential figure in mucosal immunology and gastrointestinal disease research.