Ludvig M. Sollid
Papers
2
Total Citations
383
H-Index
2
About
Ludvig M. Sollid is a world-leading immunologist whose pioneering work has fundamentally reshaped our understanding of celiac disease. His research centers on the interplay between the adaptive immune system and dietary antigens, specifically focusing on the role of the enzyme tissue transglutaminase (TG2). Sollid’s major contribution was demonstrating that TG2 is not merely a target of autoantibodies, but an active driver of the disease. He revealed that TG2 deamidates specific glutamine residues in gliadin peptides, a modification that dramatically increases their affinity for HLA-DQ2 molecules, thereby triggering a potent T-cell response. His landmark 2002 paper on "Gliadin T Cell Epitope Selection by Tissue Transglutaminase" (231 citations) and his 2004 work on "Molecular Characterization of Covalent Complexes between TG2 and Gliadin Peptides" (152 citations) established the mechanistic basis for this process. These discoveries have had a profound impact, providing the molecular framework for understanding celiac disease pathogenesis and opening new avenues for diagnostic and therapeutic strategies. Sollid’s work remains a cornerstone of mucosal immunology and gluten-related disorders.
Research Focus
Key Achievements
Top Papers
- 1Gliadin T Cell Epitope Selection by Tissue Transglutaminase in Celiac Disease231 citations · 2002
- 2