Maria Koukoula

National and Kapodistrian University of Athens

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About

Maria Koukoula is a researcher specializing in pharmacogenomics and clinical pharmacology, with a particular focus on how genetic variability influences drug metabolism and therapeutic outcomes. Her work bridges analytical chemistry and molecular biology, as exemplified by her most-cited study, which investigated the impact of CYP2C19 polymorphisms on omeprazole pharmacokinetics using validated LC–MS/MS and real-time PCR methods. This research, cited 17 times, provides critical insights into personalized medicine, demonstrating how genetic testing can optimize proton pump inhibitor therapy by predicting drug exposure and efficacy. Koukoula’s contributions are significant in advancing the understanding of genotype-guided dosing, particularly for drugs metabolized by the highly polymorphic CYP2C19 enzyme. Her methodological rigor—combining sensitive mass spectrometry with genetic analysis—has set a standard for pharmacokinetic studies in diverse populations. By elucidating the interplay between genetics and drug response, her work supports the development of tailored treatment strategies, reducing adverse effects and improving patient outcomes. Koukoula’s research is a valuable resource for students and clinicians exploring the translational potential of pharmacogenomics in routine clinical practice.