Kleopatra H. Schulpis
Papers
1
Total Citations
17
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1
About
Kleopatra H. Schulpis is a distinguished researcher in clinical biochemistry and pharmacogenomics, with a primary focus on the interplay between genetic polymorphisms and drug metabolism. Her work is particularly centered on cytochrome P450 enzymes, notably CYP2C19, and their impact on the pharmacokinetics of widely used medications like omeprazole. In her highly cited 2016 study, she employed validated LC–MS/MS and Real Time-PCR methods to investigate how CYP2C19 variants influence omeprazole clearance, providing critical insights for personalized proton pump inhibitor therapy. This research, with 17 citations, underscores her contribution to bridging molecular genetics with clinical pharmacology. Schulpis’s broader achievements include advancing the understanding of metabolic disorders and enzyme deficiencies, often in pediatric populations, and her work has been instrumental in shaping guidelines for genotype-guided dosing. Her rigorous methodological approach and translational focus make her a key figure in precision medicine, particularly for conditions requiring careful drug metabolism management.
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