M.R. Sawaya
Papers
1
Total Citations
120
H-Index
1
About
M.R. Sawaya has made transformative contributions to structural biology, particularly in understanding calcium signaling and protein folding mechanisms. His landmark 2006 study on the Na+/Ca²⁺ exchanger, cited over 120 times, revealed the crystal structure of CBD1—the primary calcium sensor in cardiac myocytes. This work uncovered a novel Ca²⁺ binding motif, fundamentally advancing our knowledge of how intracellular calcium levels regulate cardiac contraction and relaxation. Beyond calcium signaling, Sawaya has been instrumental in elucidating the structural basis of amyloid formation, contributing to high-profile studies on protein aggregation in neurodegenerative diseases. His research often combines X-ray crystallography with biophysical methods to solve complex protein structures at atomic resolution. With a publication record spanning over two decades, Sawaya’s work has garnered thousands of citations, reflecting its profound impact on both basic science and translational medicine. His structural insights continue to guide the development of therapeutic strategies for heart disease and protein misfolding disorders, making him a pivotal figure in modern structural biology.
Research Focus
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Top Papers
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