Jeff Abramson
Papers
3
Total Citations
178
H-Index
3
About
Jeff Abramson is a structural biologist whose research sits at the intersection of membrane protein biochemistry and calcium signaling, with a particular focus on the molecular mechanisms governing cardiac physiology. His most influential work centers on the Na⁺/Ca²⁺ exchanger (NCX1.1), a critical plasma membrane protein responsible for regulating intracellular calcium levels in heart muscle cells. Abramson's landmark 2006 crystallographic study, which has garnered over 120 citations, revealed the atomic structure of CBD1 — the primary calcium-sensing domain of NCX1.1 — uncovering a novel Ca²⁺ binding motif that reshaped understanding of how calcium transport is regulated in cardiac tissue. Building on this foundation, his 2009 structural and functional analysis of a CBD1 mutant further illuminated the regulatory interplay between the exchanger's two intracellular domains, CBD1 and CBD2. Beyond calcium signaling, Abramson has made methodological contributions to the field through his work on high-throughput membrane protein crystallization using the lipidic bicelle approach, helping lower technical barriers for structural studies of this notoriously challenging class of proteins. His body of work has meaningfully advanced both basic science and the potential for therapeutic interventions in cardiac disease.
Research Focus
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Top Papers
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