Papers
2
Total Citations
42
H-Index
2
About
Vincent Chaptal is a structural biologist whose research focuses on the molecular mechanisms of membrane transport and bacterial gene regulation. His work has significantly advanced our understanding of ion exchange and metabolic control, with his most-cited paper (31 citations) providing a detailed structural and functional analysis of a Ca²⁺ sensor mutant of the Na⁺/Ca²⁺ exchanger NCX1.1. This study elucidated how Ca²⁺ binding to the regulatory domains CBD1 and CBD2 governs the exchanger's activity, a critical process for cardiac contraction and calcium homeostasis. Chaptal’s contributions extend to bacterial physiology, where his structural analysis of the CcpA effector binding site in *Bacillus subtilis* (11 citations) revealed how this master regulator mediates carbon catabolite repression—a fundamental pathway that allows bacteria to prioritize glucose metabolism. By solving key protein structures, Chaptal has provided mechanistic insights into both eukaryotic ion transport and prokaryotic signal transduction, bridging disciplines to impact fields from cardiovascular biology to microbial pathogenesis. His work continues to inform drug design and synthetic biology, making him a notable figure in structural and molecular biology.
Research Focus
Key Achievements
Top Papers
- 1
- 2Structural analysis of <i>B. subtilis</i> CcpA effector binding site11 citations · 2006