Sandrine Poncet

Centre National de la Recherche Scientifique

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About

Sandrine Poncet is a leading structural biologist whose research has significantly advanced our understanding of carbon catabolite repression in Gram-positive bacteria. Her work centers on the molecular mechanisms by which bacteria regulate gene expression in response to nutrient availability, with a particular focus on the catabolite control protein A (CcpA) and its effector binding sites. Through meticulous structural analyses, Poncet has elucidated how CcpA recognizes and responds to rapidly metabolizable carbohydrates like glucose, providing fundamental insights into bacterial signal transduction pathways. Her most cited paper, "Structural analysis of B. subtilis CcpA effector binding site" (2006), has garnered 11 citations and remains a cornerstone in the field. This work has not only deepened our understanding of bacterial metabolism but also holds implications for developing novel antimicrobial strategies targeting these regulatory pathways. Poncet's contributions have established her as a key figure in bacterial regulatory biology, bridging structural biology and microbiology to unravel the intricate molecular dialogues that govern bacterial adaptation and survival.