Kenneth D. Philipson
Papers
2
Total Citations
151
H-Index
2
About
Kenneth D. Philipson is a prominent cardiovascular and cell biology researcher whose work has fundamentally advanced our understanding of calcium homeostasis in cardiac muscle cells. His research has centered on the Na⁺/Ca²⁺ exchanger (NCX1.1), a critical plasma membrane protein responsible for regulating intracellular calcium levels in cardiac myocytes — a process essential to normal heart function and rhythm. Philipson's most influential contribution came in 2006 with the elucidation of the crystal structure of CBD1, the primary calcium-sensing domain of the Na⁺/Ca²⁺ exchanger, which revealed an entirely novel calcium-binding motif and has since garnered over 120 citations. This structural breakthrough provided the field with a molecular framework for understanding how calcium governs exchanger activity. Building on this work, his 2009 study examined functionally relevant CBD1 mutations, deepening insight into how both regulatory domains CBD1 and CBD2 coordinate to fine-tune calcium efflux following cardiac contraction. Collectively, Philipson's research has shaped modern understanding of cardiac excitation-contraction coupling and has important implications for heart disease research, making him a foundational figure in the study of ion transport physiology.
Research Focus
Key Achievements
Top Papers
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