Seunghyug Kwon
Papers
1
Total Citations
120
H-Index
1
About
Seunghyug Kwon is a structural biologist whose work has fundamentally advanced our understanding of calcium signaling in the heart. His research centers on the molecular mechanisms of ion transport, with a particular focus on the Na+/Ca2+ exchanger (NCX), a critical regulator of cardiac contractility. Kwon’s landmark contribution came with the first crystal structure of the primary Ca2+ sensor of NCX, known as CBD1. This seminal 2006 study, which has garnered over 120 citations, revealed a novel Ca2+ binding motif, providing an unprecedented atomic-level view of how calcium binding triggers the exchanger’s activity. By elucidating this key regulatory domain, Kwon’s work has illuminated the fundamental principles of calcium-dependent ion transport in cardiac myocytes. His findings are not only a cornerstone for understanding normal heart function but also offer critical insights into the pathophysiology of arrhythmias and heart failure, where NCX dysregulation plays a central role. For students and researchers, Kwon’s research exemplifies how structural biology can decode the molecular logic of vital physiological processes.
Research Focus
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Top Papers
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