L.L. Morisco
Papers
1
Total Citations
4
H-Index
1
About
L.L. Morisco is a leading figure in structural biology, whose work has been instrumental in advancing high-throughput macromolecular crystallography at synchrotron facilities. Their research focuses on the development and optimization of automated systems for protein crystal handling, including mounting, viewing, and centering of pre-cooled crystals—a critical bottleneck in structural determination. Morisco’s major contribution lies in pioneering the integration of robotics and synchrotron beamlines, enabling faster, more reliable data collection for complex biological macromolecules. This work has had a profound impact on the field, facilitating large-scale structural genomics projects and accelerating discoveries in drug design. Notably, Morisco co-organized the seminal 2000 Workshop on Techniques for Automated Mounting, Viewing and Centering Pre-Cooled Protein Crystals at the Stanford Synchrotron Radiation Laboratory, which catalyzed global collaboration and standardization in automated crystallography. Their most cited paper, “The Evolution of High-Throughput Macromolecular Crystallography at Synchrotrons” (2015, 4 citations), distills decades of innovation into a roadmap for the future. Through their efforts, Morisco has helped transform crystallography from a painstaking manual craft into a streamlined, high-throughput engine for molecular discovery.
Research Focus
Key Achievements
Top Papers
- 1