John F. Newton
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108
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About
Dr. John F. Newton is a pioneer in bioanalytical chemistry, whose work has fundamentally transformed high-throughput drug metabolism and pharmacokinetic studies. His most influential contribution lies in revolutionizing sample preparation for liquid chromatography-tandem mass spectrometry (LC/MS/MS) bioanalysis. His seminal 1998 paper, cited over 108 times, introduced the groundbreaking use of a 96-well disk solid phase extraction (SPE) plate operated by a robotic system. This innovation enabled the simultaneous extraction of 96 biological samples, dramatically accelerating the analysis of drugs and their metabolites. By employing a disk as the sorbent, Newton further enhanced the efficiency and reproducibility of the process, setting a new industry standard for speed and reliability in bioanalysis. His work has been instrumental in enabling the rapid, high-throughput screening essential for modern drug discovery and development. Dr. Newton’s contributions remain a cornerstone of bioanalytical methodology, profoundly impacting how researchers process complex biological matrices and advancing the pace of pharmaceutical research.
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