Danlin Wu

Papers

Total Citations

108

H-Index

About

Dr. Danlin Wu has made foundational contributions to high-throughput bioanalytical chemistry, particularly in the development of rapid sample preparation techniques for liquid chromatography-tandem mass spectrometry (LC/MS/MS). Their most cited work, a 1998 study on 96-well disk solid phase extraction (SPE) plates, revolutionized the field by enabling the simultaneous, robot-assisted extraction of 96 biological samples—dramatically accelerating the analysis of drugs and metabolites in complex matrices. This innovation, which replaced traditional column-based sorbents with a disk format, improved both throughput and reproducibility, earning over 108 citations and becoming a standard approach in pharmaceutical bioanalysis. Dr. Wu’s research addresses critical bottlenecks in drug development and clinical pharmacokinetics, bridging the gap between automation and analytical sensitivity. Their work is widely recognized for its practical impact on reducing sample preparation time while maintaining data quality, a key challenge in high-volume LC/MS/MS workflows. By integrating engineering principles with analytical chemistry, Dr. Wu has enabled faster, more reliable bioanalysis, directly supporting advances in personalized medicine and therapeutic drug monitoring. Their contributions remain essential reading for researchers seeking efficient, scalable solutions in mass spectrometry-based bioanalysis.