Michael Kealy
Papers
1
Total Citations
108
H-Index
1
About
Dr. Michael Kealy is a pioneering figure in bioanalytical chemistry, whose work has fundamentally accelerated the pace of pharmaceutical development. His primary research focus lies in high-throughput sample preparation and liquid chromatography/mass spectrometry (LC/MS) bioanalysis, specifically for the quantification of drugs and their metabolites in complex biological matrices. Dr. Kealy’s most significant contribution is his seminal 1998 paper on the 96-well disk solid phase extraction (SPE) plate, which has garnered 108 citations. This work revolutionized the field by demonstrating how robotic automation of a 96-well disk format could simultaneously prepare nearly 100 samples, dramatically reducing analysis time while improving reproducibility. By integrating a disk sorbent into the plate, he solved critical issues of clogging and flow inconsistency, setting a new standard for efficiency in bioanalysis. This innovation has become a cornerstone technique in modern drug metabolism and pharmacokinetics (DMPK) labs, enabling the rapid screening of thousands of compounds. Dr. Kealy’s work remains a benchmark for researchers seeking to merge speed, sensitivity, and reliability in quantitative bioanalysis.
Research Focus
Key Achievements
Top Papers
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