Heidi Simpson

Papers

Total Citations

108

H-Index

About

Dr. Heidi Simpson is a pioneering figure in bioanalytical chemistry, best known for her transformative work in high-throughput mass spectrometry. Her research centers on advancing liquid chromatography/tandem mass spectrometry (LC/MS/MS) methodologies, with a particular focus on automating sample preparation for pharmacokinetic and drug metabolism studies. Her most cited work, "High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation" (1998, 108 citations), introduced a groundbreaking approach that combined robotic automation with 96-well solid phase extraction (SPE) plates. By employing a disk as the sorbent, this method enabled the simultaneous extraction of 96 samples from biological matrices, dramatically accelerating the bioanalysis of drugs and their metabolites. This innovation not only improved throughput and reproducibility but also set a new standard for efficiency in pharmaceutical development. With over 100 citations, her work remains a foundational reference in bioanalysis, demonstrating lasting impact on how researchers prepare complex biological samples for mass spectrometric analysis. Dr. Simpson’s contributions continue to inspire advances in high-speed, automated analytical workflows.