Geraldo Aleixo Silva Passos
Papers
2
Total Citations
25
H-Index
2
About
Geraldo Aleixo Silva Passos is a researcher whose work focuses on the genetic and molecular underpinnings of type 1 diabetes (T1D), with a particular emphasis on gene expression profiling and susceptibility regions. His major contributions include identifying and characterizing differentially expressed genes in lymphomononuclear cells from recently diagnosed T1D patients, revealing that metabolism genes are among the most prominently altered. He also stratified gene expression profiles according to known T1D susceptibility regions, such as the MHC region on chromosome 6p21, as well as loci on 1p13 (PTPN22), 2q33 (CTLA-4), and 11p15 (insulin). These studies, published in 2008 and 2006, have collectively garnered over 25 citations, underscoring their relevance to the immunogenetics of autoimmune diabetes. Passos’s work provides foundational insights into how genetic risk variants influence transcriptional programs in immune cells, offering a bridge between genomic susceptibility and disease pathogenesis. His research is particularly valuable for students and researchers interested in the intersection of genomics, immunology, and metabolic regulation in T1D.
Research Focus
Key Achievements
Top Papers
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- 2