Guilherme Liberato da Silva
Papers
1
Total Citations
16
H-Index
1
About
Guilherme Liberato da Silva is a researcher whose work lies at the intersection of immunogenetics and complex disease susceptibility, with a particular focus on type 1 diabetes mellitus (T1D). His major contributions center on elucidating how genetic variation—especially within the major histocompatibility complex (MHC) region on chromosome 6p21—drives differential gene expression and autoimmune risk. In his most cited work (2008, 16 citations), Silva stratified gene expression profiles according to established T1D susceptibility loci, including the MHC, PTPN22, CTLA-4, and the insulin gene region. This study provided an early, integrated view of how multiple risk variants collectively shape the transcriptional landscape in T1D, moving beyond single-gene analyses to a more systems-level understanding. While his citation count reflects a focused, niche impact rather than broad notoriety, Silva’s approach—combining linkage data with expression profiling—was methodologically ahead of its time and has informed subsequent efforts to map functional variants in autoimmune disease. His work remains a valuable reference for researchers exploring the regulatory consequences of T1D risk haplotypes.
Research Focus
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Top Papers
- 1