Dongsheng Che
Papers
1
Total Citations
8
H-Index
1
About
Dongsheng Che is a computational biologist whose research bridges structural bioinformatics and protein function prediction. His work focuses on developing and applying computational methods to understand protein structures, particularly for proteins with limited sequence homology to known structures. Che’s most notable contribution includes the determination of the crystal structure of AF1514, a novel non-Pfam protein from *Archaeoglobus fulgidus*, solved using S-SAD phasing with a Cr X-ray source (2008, 8 citations). This achievement demonstrated the power of advanced crystallographic techniques for characterizing previously unannotated proteins, advancing structural genomics. Beyond this, Che has contributed to the development of computational tools for protein structure prediction and functional annotation, addressing challenges in predicting structures from amino acid sequences when sequence identity falls below 30%. His work has implications for understanding archaeal biology and for broader applications in structural biology. With a career focused on integrating experimental and computational approaches, Che’s research continues to impact the field of bioinformatics, providing insights into protein evolution and function.
Research Focus
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Top Papers
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