Neil Shaw
Papers
1
Total Citations
8
H-Index
1
About
Neil Shaw is a structural biologist whose research focuses on elucidating the three-dimensional architecture of proteins, particularly those from extremophilic organisms and those lacking sequence homology to known structures. His work is central to understanding how novel proteins fold and function, often employing cutting-edge crystallographic techniques. Shaw’s major contributions include the determination of the crystal structure of AF1514 from *Archaeoglobus fulgidus*, a protein with no sequence similarity to any known Pfam family. This achievement was notable for being solved using the S-SAD (single-wavelength anomalous dispersion) method with a chromium X-ray source, a technically demanding approach that demonstrated the power of low-energy phasing for challenging targets. While his most-cited paper has 8 citations, its impact lies in methodological advancement, showcasing a viable path for solving structures of “non-Pfam” proteins that evade traditional homology modeling. Shaw’s work underscores the importance of experimental structure determination in expanding our understanding of protein fold space, particularly for organisms thriving in extreme environments. His research continues to provide foundational insights for structural genomics and the development of computational prediction tools.
Research Focus
Key Achievements
Top Papers
- 1